Product Data Sheet
UK-101
Catalog No. A30798
UK-101 is a selective inhibitor of the immunoproteasome β1i subunit (LMP2), exhibiting an IC50 value of 104 nM. With significant selectivity, it demonstrates 144-fold and 10-fold inhibition over the β1c (IC50=15 μM) and β5 subunits (IC50=1 μM), respectively. UK-101 promotes apoptosis in cancer cells, making it a valuable tool for researching prostate cancer and related therapeutic pathways.
Chemical Information
| Catalog Num | A30798 |
|---|---|
| M. Wt | 484.74 |
| Formula | C25H48N2O5Si |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1000313-40-5 |
| Synonyms | |
| SMILES | O=C([C@]1(CO1)CO[Si](C)(C)C(C)(C)C)[C@H](CC(C)C)NC([C@H](C)NC(CCCCCC)=O)=O |
| Storage |
Biological Activity
| Discription | UK-101 is a selective inhibitor of the immunoproteasome β1i subunit (LMP2), exhibiting an IC50 value of 104 nM. With significant selectivity, it demonstrates 144-fold and 10-fold inhibition over the β1c (IC50=15 μM) and β5 subunits (IC50=1 μM), respectively. UK-101 promotes apoptosis in cancer cells, making it a valuable tool for researching prostate cancer and related therapeutic pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
