Product Data Sheet
Ibandronate Sodium
Catalog No. A31471
Ibandronate Sodium is a specific inhibitor of farnesyl pyrophosphate synthase (FPP synthase), functioning primarily through the inhibition of the mevalonate pathway. This compound effectively disrupts isoprenylation of small GTPases, including RAS and RHO family proteins, leading to tumor cell apoptosis and decreased bone resorption. Ibandronate Sodium has demonstrated the ability to hinder ER+ breast cancer cell proliferation, increase expression of the pro-apoptotic gene FAS, and exhibit synergistic anti-tumor effects with anti-estrogen agents. Its applications extend to investigating osteoporosis and the mechanisms underlying bone metastasis in tumors, particularly those involving breast cancer.
Chemical Information
| Catalog Num | A31471 |
|---|---|
| M. Wt | 341.21 |
| Formula | C9H22NNaO7P2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 138844-81-2 |
| Synonyms | |
| SMILES | OC(P(O)(O)=O)(P(O)([O-])=O)CCN(C)CCCCC.[Na+] |
| Storage |
Biological Activity
| Discription | Ibandronate Sodium is a specific inhibitor of farnesyl pyrophosphate synthase (FPP synthase), functioning primarily through the inhibition of the mevalonate pathway. This compound effectively disrupts isoprenylation of small GTPases, including RAS and RHO family proteins, leading to tumor cell apoptosis and decreased bone resorption. Ibandronate Sodium has demonstrated the ability to hinder ER+ breast cancer cell proliferation, increase expression of the pro-apoptotic gene FAS, and exhibit synergistic anti-tumor effects with anti-estrogen agents. Its applications extend to investigating osteoporosis and the mechanisms underlying bone metastasis in tumors, particularly those involving breast cancer. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
