Product Data Sheet
JNJ-63576253
Catalog No. A84935
JNJ-63576253 is a potent and orally active antagonist of the androgen receptor (AR), exhibiting IC50 values of 37 nM for the F877L mutant AR and 54 nM for wild-type AR in LNCaP cells. This compound serves as a valuable tool for investigating androgen receptor signaling pathways and is particularly relevant for research on castration-resistant prostate cancer (CRPC). Its efficacy in blocking AR activity makes it a significant candidate for therapeutic studies targeting advanced prostate carcinoma.
Chemical Information
| Catalog Num | A84935 |
|---|---|
| M. Wt | 538.97 |
| Formula | C23H22ClF3N6O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2110428-64-1 |
| Synonyms | TRC-253 |
| SMILES | [H]Cl.O=C(N(C(N1C2=CC=C(N=C2)OC3CCNCC3)=S)C(C=C4C(F)(F)F)=CN=C4C#N)C51CCC5 |
| Storage |
Biological Activity
| Discription | JNJ-63576253 is a potent and orally active antagonist of the androgen receptor (AR), exhibiting IC50 values of 37 nM for the F877L mutant AR and 54 nM for wild-type AR in LNCaP cells. This compound serves as a valuable tool for investigating androgen receptor signaling pathways and is particularly relevant for research on castration-resistant prostate cancer (CRPC). Its efficacy in blocking AR activity makes it a significant candidate for therapeutic studies targeting advanced prostate carcinoma. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
