17-AAG (KOS953)

Catalog No. A10010

17-AAG (KOS953)是一种有效的HSP90抑制剂，无细胞试验中IC50为5 nM，作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。

Product Citations

Yool Lee, .et al. Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle, Sci Adv, 2021, 7

Technical details

Catalog Num	A10010
M. Wt	585.7
Formula	C31H43N3O8
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	75747-14-7
Synonyms	Tanespimycin, NSC330507, CP 127374, KOS-953, KOS 953
SMILES	CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC

Biological Activity

17-AAG (KOS953)是一种有效的HSP90抑制剂，无细胞试验中IC50为5 nM，作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。

Targets

HSP90 (Cell-free assay)
5 nM

Solubility *

In vitro (25°C)	DMSO	97 mg/mL (165.61 mM)
	Water	Insoluble
	Ethanol	5 mg/mL
In vivo	5%DMSO+corn oil	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.07 mL	85.37 mL	170.74 mL
0.5 mM	3.41 mL	17.07 mL	34.15 mL
1 mM	1.71 mL	8.54 mL	17.07 mL
5 mM	0.34 mL	1.71 mL	3.41 mL

*The above data is based on the productmolecular weight 585.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.