A-966492

Catalog No. A10019

A-966492在全细胞试验中显示出对K（i）为1 nM，EC（50）为1 nM的聚（ADP-核糖）聚合酶-1（PARP-1）酶的高效力。

Technical details

Catalog Num	A10019
M. Wt	324.4
Formula	C18H17FN4O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	934162-61-5
Synonyms	A966492
SMILES	C1CC(NC1)C2=CC(=C(C=C2)C3=NC4=C(C=CC=C4N3)C(=O)N)F

Biological Activity

A-966492在全细胞试验中显示出对K（i）为1 nM，EC（50）为1 nM的聚（ADP-核糖）聚合酶-1（PARP-1）酶的高效力。

Targets

PARP1	PARP1	PARP2
1 nM(Ki)	1 nM(EC50)	1.5 nM(Ki)

Solubility *

In vitro	DMSO	Warmed: 60 mg/mL (184.98 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.83 mL	154.13 mL	308.26 mL
0.5 mM	6.17 mL	30.83 mL	61.65 mL
1 mM	3.08 mL	15.41 mL	30.83 mL
5 mM	0.62 mL	3.08 mL	6.17 mL

*The above data is based on the productmolecular weight 324.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.