ABT-751 (E-7010)

Catalog No. A10024

ABT-751 (E-7010)是一种抗有丝分裂剂，可抑制微管聚合，并在秋水仙碱位点与β-微管蛋白结合。在G2M期阻断细胞周期并诱导凋亡。

Technical details

Catalog Num	A10024
M. Wt	371.4
Formula	C18H17N3O4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	141430-65-1
Synonyms	ABT751
SMILES	COC1=CC=C(C=C1)S(=O)(=O)NC2=C(N=CC=C2)NC3=CC=C(C=C3)O

Biological Activity

ABT-751 (E-7010)是一种抗有丝分裂剂，可抑制微管聚合，并在秋水仙碱位点与β-微管蛋白结合。在G2M期阻断细胞周期并诱导凋亡。

Targets

Microtubules

Solubility *

In vitro (25°C)	DMSO	71 mg/mL (191.16 mM)
	Water	Insoluble
	Ethanol	12 mg/mL (32.3 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.93 mL	134.63 mL	269.25 mL
0.5 mM	5.39 mL	26.93 mL	53.85 mL
1 mM	2.69 mL	13.46 mL	26.93 mL
5 mM	0.54 mL	2.69 mL	5.39 mL

*The above data is based on the productmolecular weight 371.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.