ABT-888 (Veliparib)

Catalog No. A10026

ABT-888 (Veliparib)是一种潜在的抗癌药物，可作为PARP抑制剂。

Product Citations

Subhajit Chatterjee, .et al. PARP inhibitor Veliparib (ABT-888) enhances the anti-angiogenic potentiality of Curcumin through deregulation of NECTIN-4 in oral cancer: Role of nitric oxide (NO), Cell Signal, 2021, Apr;80:109902 PMID: 33373686

Technical details

Catalog Num	A10026
M. Wt	244.3
Formula	C13H16N4O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	912444-00-9
Synonyms	ABT888
SMILES	O=C(C1=C2NC([C@@]3(NCCC3)C)=NC2=CC=C1)N

Biological Activity

ABT-888 (Veliparib)是一种潜在的抗癌药物，可作为PARP抑制剂。

Solubility *

In vitro (25°C)	DMSO	17 mg/mL (69.58 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% methylcellulose+0.2% Tween 80	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	40.93 mL	204.67 mL	409.33 mL
0.5 mM	8.19 mL	40.93 mL	81.87 mL
1 mM	4.09 mL	20.47 mL	40.93 mL
5 mM	0.82 mL	4.09 mL	8.19 mL

*The above data is based on the productmolecular weight 244.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.