AC220 (Quizartinib)

Catalog No. A10027

AC220 (Quizartinib)是一种有效的选择性FLT3抑制剂，对于MC4-11和A375，IC50分别为0.56±0.3 nM和> 10 mM。

Product Citations

N Naganna, .et al. Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice, EBioMedicine, 2019, Jan 24. pii: S2352-3964(19)30012-X PMID: 30686755
Cong Li, .et al. AMG 925 is a dual FLT3/CDK4 inhibitor with the potential to overcome FLT3 inhibitor resistance in acute myeloid leukemia., Mol Cancer Ther., 2015, Feb;14(2):375-83. PMID: 25487917
Yaping Zhang, .et al. FLT3 and CDK4/6 inhibitors: Signaling mechanisms and tumor burden in subcutaneous and orthotopic mouse models of acute myeloid leukemia, J Pharmacokinet Pharmacodyn., 2014, 41(6): 675-691. PMID: 25326874

Technical details

Catalog Num	A10027
M. Wt	560.7
Formula	C29H32N6O4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	950769-58-1
Synonyms
SMILES	CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C=C5)OCCN6CCOCC6)SC4=N3

Biological Activity

AC220 (Quizartinib)是一种有效的选择性FLT3抑制剂，对于MC4-11和A375，IC50分别为0.56±0.3 nM和> 10 mM。

Targets

FLT3 (ITD) (MV4-11 cells)	FLT3 (WT) (RS4;11 cells)
1.1 nM	4.2 nM

Solubility *

In vitro (25°C)	DMSO	29 mg/mL (51.72 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	15% Captisol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.83 mL	89.17 mL	178.35 mL
0.5 mM	3.57 mL	17.83 mL	35.67 mL
1 mM	1.78 mL	8.92 mL	17.83 mL
5 mM	0.36 mL	1.78 mL	3.57 mL

*The above data is based on the productmolecular weight 560.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.