Acadesine (Aicar,NSC 105823)

Catalog No. A10028

Acadesine (Aicar,NSC 105823)是肝细胞和脂肪细胞中AMPK的选择性激活剂。

Product Citations

R. Lim, .et al. Activation of AMPK in human fetal membranes alleviates infection-induced expression of pro-inflammatory and pro-labour mediators., Placenta, 2015, Apr;36(4):454-62 PMID: 25659498
Stella Liong, .et al. Activation of AMPK improves inflammation and insulin resistance in adipose tissue and skeletal muscle from pregnant women., J Physiol Biochem, 2015, Dec;71(4):703-17 PMID: 26407807

Technical details

Catalog Num	A10028
M. Wt	258.2
Formula	C9H14N4O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	2627-69-2
Synonyms	AICAR, AICA-riboside, NSC-105823, NSC105823
SMILES	C1=NC(=C(N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N)C(=O)N

Biological Activity

Acadesine (Aicar,NSC 105823)是肝细胞和脂肪细胞中AMPK的选择性激活剂。

Targets

AMPK (Cell-free assay)	AMPKK (Cell-free assay)

Solubility *

In vitro (25°C)	DMSO	44 mg/mL (170.38 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+40% PEG 300+2% Tween 80+ddH2O	5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	38.73 mL	193.65 mL	387.3 mL
0.5 mM	7.75 mL	38.73 mL	77.46 mL
1 mM	3.87 mL	19.36 mL	38.73 mL
5 mM	0.77 mL	3.87 mL	7.75 mL

*The above data is based on the productmolecular weight 258.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.