Cycloheximide (Actidione)

Catalog No. A10036

Cycloheximide (Actidione)用作选择性抗生素。它抑制腐菌真菌真核生物的蛋白质合成(DNA依赖性RNA)。通过与80S核糖体结合而对皮肤真菌和系统性真菌无效。

Product Citations

Ke Chen, .et al. Junction plakoglobin regulates and destabilizes HIF2α to inhibit tumorigenesis of renal cell carcinoma, Cancer Commun (Lond), 2021, Apr; 41(4): 316-332 PMID: 33591636
Zhiyuan Qin, .et al. miR-224-5p Contained in Urinary Extracellular Vesicles Regulates PD-L1 Expression by Inhibiting Cyclin D1 in Renal Cell Carcinoma Cells, Cancers (Basel), 2021, Feb 4;13(4):618 PMID: 33557163
Hua Xu, .et al. Preclinical Study Using ABT263 to Increase Enzalutamide Sensitivity to Suppress Prostate Cancer Progression Via Targeting BCL2/ROS/USP26 Axis Through Altering ARv7 Protein Degradation, Cancers (Basel), 2020, Apr; 12(4): 831 PMID: 32235588

Technical details

Catalog Num	A10036
M. Wt	281.4
Formula	C15H23NO4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	66-81-9
Synonyms
SMILES	C[C@H]1C[C@@H](C(=O)[C@@H](C1)[C@@H](CC2CC(=O)NC(=O)C2)O)C

Biological Activity

Cycloheximide (Actidione)用作选择性抗生素。它抑制腐菌真菌真核生物的蛋白质合成(DNA依赖性RNA)。通过与80S核糖体结合而对皮肤真菌和系统性真菌无效。

Solubility *

In vitro	DMSO	48 mg/mL (170.61 mM)
	Water	13 mg/mL (46.2 mM)
	Ethanol	48 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	35.54 mL	177.68 mL	355.37 mL
0.5 mM	7.11 mL	35.54 mL	71.07 mL
1 mM	3.55 mL	17.77 mL	35.54 mL
5 mM	0.71 mL	3.55 mL	7.11 mL

*The above data is based on the productmolecular weight 281.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.