AG-014699 (Rucaparib)

Catalog No. A10045

AG-014699 (Rucaparib)是一种PARP抑制剂，可抑制聚（ADP-核糖）聚合酶（PARP，后者是DNA修复中的关键酶。无细胞试验中作用于PARP1的Ki为1.4 nM，对其余8个PARP位点也有结合亲和力。

Product Citations

Tahira Baloch, .et al. Sequential therapeutic targeting of ovarian Cancer harboring dysfunctional BRCA1, BMC Cancer, 2019, Jan 10;19(1):44 PMID: 30630446

Technical details

Catalog Num	A10045
M. Wt	421.4
Formula	C19H18FN3O.H3PO4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	459868-92-9
Synonyms	AG014699, PF-01367338,AG-014447 (as free base)
SMILES	CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=CC(=CC(=C34)N2)F.OP(=O)(O)O

Biological Activity

Targets

PARP (Cell-free assay)
1.4 nM(Ki)

Solubility *

In vitro (25°C)	DMSO	81 mg/mL (192.23 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.73 mL	118.65 mL	237.3 mL
0.5 mM	4.75 mL	23.73 mL	47.46 mL
1 mM	2.37 mL	11.87 mL	23.73 mL
5 mM	0.47 mL	2.37 mL	4.75 mL

*The above data is based on the productmolecular weight 421.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.