AG-490

Catalog No. A10047

AG 490是EGF受体酪氨酸激酶的选择性抑制剂 (EGFR和ErbB2的IC50值分别为2和13.5μM)。也抑制对Lck，Lyn，Btk，Syk和Src无活性的JAK2。

Product Citations

Matozaki M, .et al. Involvement of Stat3 phosphorylation in mild heat shock-induced thermotolerance, Exp Cell Res, 2019, Feb 15. pii: S0014-4827(18)31030-9 PMID: 30776355

Technical details

Catalog Num	A10047
M. Wt	294.3
Formula	C17H14N2O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	133550-30-8
Synonyms	Tyrphostin AG490
SMILES	C1=CC=C(C=C1)CNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N

Biological Activity

AG 490是EGF受体酪氨酸激酶的选择性抑制剂 (EGFR和ErbB2的IC50值分别为2和13.5μM)。也抑制对Lck，Lyn，Btk，Syk和Src无活性的JAK2。

Targets

EGFR (Cell-free assay)	JAK2 (Cell-free assay)	ErbB2 (Cell-free assay)
0.1 μM	~10 μM	13.5 μM

Solubility *

In vitro (25°C)	DMSO	54 mg/mL (183.48 mM)
	Water	Insoluble
	Ethanol	6 mg/mL
In vivo	5% DMSO+40% PEG300+5% Tween80+50% ddH2O	5.93 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	33.98 mL	169.89 mL	339.79 mL
0.5 mM	6.8 mL	33.98 mL	67.96 mL
1 mM	3.4 mL	16.99 mL	33.98 mL
5 mM	0.68 mL	3.4 mL	6.8 mL

*The above data is based on the productmolecular weight 294.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.