AST-6

Catalog No. A10062

AST-6是表皮生长因子受体1和2的新型不可逆抑制剂，可在体内外抑制肿瘤生长。

Technical details

Catalog Num	A10062
M. Wt	621.1
Formula	C24H18ClFN4O2.C7H8O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1050500-29-2
Synonyms	AST6
SMILES	CC1=CC=C(C=C1)S(=O)(=O)O.C=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=C(C=C3)OCC4=CC(=CC=C4)F)Cl

Biological Activity

AST-6是表皮生长因子受体1和2的新型不可逆抑制剂，可在体内外抑制肿瘤生长。

Targets

Target	Value
EGFR	IC50: 0.5nM
ErbB4	IC50: 0.8nM
ErbB2	IC50: 3.0nM
EGFR(T790M/L858R)	IC50: 12nM
FLT1	IC50: >10μM
KDR	IC50: >10μM
PDGFRα	IC50: >10μM
PDGFRβ	IC50: >10μM
c-Src	IC50: >10μM
c-Met	IC50: >10μM
c-Kit	IC50: >10μM
IGF-1R	IC50: >10μM
FGFR1	IC50: >10μM
RON	IC50: >10μM
Abl	IC50: >10μM
EphA2	IC50: >10μM
EphB2	IC50: >10μM
Tie-2	IC50: >10μM
Syk	IC50: >10μM
PKCβ2	IC50: >10μM
p70S6K	IC50: >10μM
JAK2	IC50: >10μM
Pim2	IC50: >10μM
Akt1	IC50: >10μM
AuroraA	IC50: >10μM
CDK2	IC50: >10μM
GSK-3β	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	115 mg/mL (185.16 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% hydroxyethyl cellulose	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.1 mL	80.5 mL	161 mL
0.5 mM	3.22 mL	16.1 mL	32.2 mL
1 mM	1.61 mL	8.05 mL	16.1 mL
5 mM	0.32 mL	1.61 mL	3.22 mL

*The above data is based on the productmolecular weight 621.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.