AMG 208

Catalog No. A10063

AMG 208是一种新型c-Met抑制剂,可抑制c-Met的配体依赖性和配体依赖性活化,从而抑制其酪氨酸激酶活性。
Catalog Num A10063
M. Wt 383.4
Formula C22H17N5O2
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1002304-34-8
Synonyms AMG208, AMG-208
SMILES COC1=CC2=NC=CC(=C2C=C1)OCC3=NN=C4N3N=C(C=C4)C5=CC=CC=C5
AMG 208是一种新型c-Met抑制剂,可抑制c-Met的配体依赖性和配体依赖性活化,从而抑制其酪氨酸激酶活性。
Targets
c-Met
9 nM
In vitro (25°C) DMSO 0.22 mg/mL (0.57 mM)
Water Insoluble
Ethanol Insoluble
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.08 mL 130.41 mL 260.82 mL
0.5 mM 5.22 mL 26.08 mL 52.16 mL
1 mM 2.61 mL 13.04 mL 26.08 mL
5 mM 0.52 mL 2.61 mL 5.22 mL

*The above data is based on the productmolecular weight 383.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.