AMG 208
Catalog No. A10063
AMG 208是一种新型c-Met抑制剂,可抑制c-Met的配体依赖性和配体依赖性活化,从而抑制其酪氨酸激酶活性。
Catalog Num | A10063 |
---|---|
M. Wt | 383.4 |
Formula | C22H17N5O2 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 1002304-34-8 |
Synonyms | AMG208, AMG-208 |
SMILES | COC1=CC2=NC=CC(=C2C=C1)OCC3=NN=C4N3N=C(C=C4)C5=CC=CC=C5 |
AMG 208是一种新型c-Met抑制剂,可抑制c-Met的配体依赖性和配体依赖性活化,从而抑制其酪氨酸激酶活性。
Targets
c-Met | ||||
9 nM |
In vitro (25°C) | DMSO | 0.22 mg/mL (0.57 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 26.08 mL | 130.41 mL | 260.82 mL |
0.5 mM | 5.22 mL | 26.08 mL | 52.16 mL |
1 mM | 2.61 mL | 13.04 mL | 26.08 mL |
5 mM | 0.52 mL | 2.61 mL | 5.22 mL |
*The above data is based on the productmolecular weight 383.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.