Amonafide (AS1413)

Catalog No. A10071

Amonafide (AS1413)是一种DNA插入剂和拓扑异构酶II抑制剂，是治疗肿瘤疾病的抗肿瘤药物之一。

Product Citations

Veronica Rendo, .et al. Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy, Nat Commun, 2020, 11: 1308 PMID: 32161261

Technical details

Catalog Num	A10071
M. Wt	283.3
Formula	C16H17N3O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	69408-81-7
Synonyms	AS1413, Xanafide, Quinamed
SMILES	CN(C)CCN1C(=O)C2=CC=CC3=CC(=CC(=C32)C1=O)N

Biological Activity

Amonafide (AS1413)是一种DNA插入剂和拓扑异构酶II抑制剂，是治疗肿瘤疾病的抗肿瘤药物之一。

Targets

Topo II

Solubility *

In vitro	DMSO	51 mg/mL (179.99 mM)
	Water	Insoluble
	Ethanol	4 mg/mL (14.11 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	35.3 mL	176.49 mL	352.98 mL
0.5 mM	7.06 mL	35.3 mL	70.6 mL
1 mM	3.53 mL	17.65 mL	35.3 mL
5 mM	0.71 mL	3.53 mL	7.06 mL

*The above data is based on the productmolecular weight 283.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.