Amphotericin B

Catalog No. A10073

Amphotericin B是来自链霉菌属的多烯抗真菌抗生素。Amphotericin B诱导K+泄漏，这与其致死作用是分开的，正如在人类红细胞中所证明的，这是由于对Na+/K+泵的抑制作用所致。

Product Citations

J Chen, .et al. Exosomal miRNA-486-5p Derived From Rheumatoid Arthritis Fibroblast-Like Synoviocytes Induces Osteoblast Differentiation Through the Tob1/BMP/Smad Pathway, Biomater Sci, 2020, Jun 21;8(12):3430-3442 PMID: 32406432

Technical details

Catalog Num	A10073
M. Wt	924.1
Formula	C47H73NO17
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1397-89-3
Synonyms	Fungilin, Fungizone, AmBisome, Fungisome, Amphocil, Amphotec
SMILES	C[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](C[C@H]2[C@@H]([C@H](C[C@](O2)(C[C@H](C[C@H]([C@@H](CC[C@H](C[C@H](CC(=O)O[C@H]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[C@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)O)N)O

Biological Activity

Targets

ergosterol

Solubility *

In vitro	DMSO	20 mg/mL (21.64 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	10.82 mL	54.11 mL	108.21 mL
0.5 mM	2.16 mL	10.82 mL	21.64 mL
1 mM	1.08 mL	5.41 mL	10.82 mL
5 mM	0.22 mL	1.08 mL	2.16 mL

*The above data is based on the productmolecular weight 924.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.