Apixaban (BMS-562247-01)

Catalog No. A10082

Apixaban (BMS-562247-01)是一种抗凝剂,用于预防静脉血栓栓塞和静脉血栓栓塞事件。
  • Daniël Verhoef, .et al. Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors, Nat Commun, 2017, 8: 528 PMID: 28904343
Catalog Num A10082
M. Wt 459.5
Formula C25H25N5O4
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 503612-47-3
Synonyms BMS-562247-01
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Apixaban (BMS-562247-01)是一种抗凝剂,用于预防静脉血栓栓塞和静脉血栓栓塞事件。
Targets
Factor Xa (human) (Cell-free assay) Factor Xa (rabbit) (Cell-free assay)
0.08 nM(Ki)0.17 nM(Ki)
In vitro (25°C) DMSO 17 mg/mL (36.99 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% PEG 400+0.5% Tween 80+5% Propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.76 mL 108.81 mL 217.63 mL
0.5 mM 4.35 mL 21.76 mL 43.53 mL
1 mM 2.18 mL 10.88 mL 21.76 mL
5 mM 0.44 mL 2.18 mL 4.35 mL

*The above data is based on the productmolecular weight 459.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.