Apixaban (BMS-562247-01)
Catalog No. A10082
Apixaban (BMS-562247-01)是一种抗凝剂,用于预防静脉血栓栓塞和静脉血栓栓塞事件。
- Daniël Verhoef, .et al. Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors, Nat Commun, 2017, 8: 528 PMID: 28904343
Catalog Num | A10082 |
---|---|
M. Wt | 459.5 |
Formula | C25H25N5O4 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 503612-47-3 |
Synonyms | BMS-562247-01 |
SMILES | COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N |
Apixaban (BMS-562247-01)是一种抗凝剂,用于预防静脉血栓栓塞和静脉血栓栓塞事件。
Targets
Factor Xa (human) (Cell-free assay) | Factor Xa (rabbit) (Cell-free assay) | |||
0.08 nM(Ki) | 0.17 nM(Ki) |
In vitro (25°C) | DMSO | 17 mg/mL (36.99 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 30% PEG 400+0.5% Tween 80+5% Propylene glycol | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 21.76 mL | 108.81 mL | 217.63 mL |
0.5 mM | 4.35 mL | 21.76 mL | 43.53 mL |
1 mM | 2.18 mL | 10.88 mL | 21.76 mL |
5 mM | 0.44 mL | 2.18 mL | 4.35 mL |
*The above data is based on the productmolecular weight 459.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.