Aprepitant (MK-0869)

Catalog No. A10083

Aprepitant (MK-0869)被归类为NK1拮抗剂。已经显示，阿瑞匹坦通过阻止P物质降落在大脑神经元受体上，从而抑制细胞毒性化疗药物引起的急性呕吐和延迟呕吐。还显示出它能增加5-HT3受体拮抗剂恩丹西酮和皮质类固醇地塞米松的活性，它们也可用于预防化学疗法引起的恶心和呕吐。

Product Citations

Kodji X, .et al. Sensory nerves mediate spontaneous behaviors in addition to inflammation in a murine model of psoriasis, FASEB J, 2018, Sep 11:fj201800395RR PMID: 30204499

Technical details

Catalog Num	A10083
M. Wt	534.4
Formula	C23H21F7N4O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	170729-80-3
Synonyms	MK0869, MK-869, L-754030, Emend
SMILES	C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NC(=O)NN3)C4=CC=C(C=C4)F

Biological Activity

Targets

Neurokinin-1 receptor (Cell-free assay)
0.1 nM

Solubility *

In vitro (25°C)	DMSO	96 mg/mL (179.63 mM)
	Water	Insoluble
	Ethanol	14 mg/mL (26.19 mM)
In vivo	5% DMSO+corn oil	12 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.71 mL	93.56 mL	187.13 mL
0.5 mM	3.74 mL	18.71 mL	37.43 mL
1 mM	1.87 mL	9.36 mL	18.71 mL
5 mM	0.37 mL	1.87 mL	3.74 mL

*The above data is based on the productmolecular weight 534.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.