AS-605240

Catalog No. A10088

AS-605240是PI3激酶γ抑制剂，以ATP竞争的方式抑制人重组PI3Kγ，α，β和δ，IC50值为8、60、270和300 nM。

Technical details

Catalog Num	A10088
M. Wt	257.3
Formula	C12H7N3O2S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	648450-29-7
Synonyms	AS605240
SMILES	C1=CC2=NC=CN=C2C=C1/C=C\3/C(=O)NC(=O)S3

Biological Activity

AS-605240是PI3激酶γ抑制剂，以ATP竞争的方式抑制人重组PI3Kγ，α，β和δ，IC50值为8、60、270和300 nM。

Targets

PI3Kγ (Cell-free assay)	PI3Kα (Cell-free assay)	PI3Kβ (Cell-free assay)	PI3Kδ (Cell-free assay)
8 nM	60 nM	270 nM	300 nM

Solubility *

In vitro (25°C)	DMSO	0.38 mg/mL (1.47 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% CMC+0.25% Tween 80	10 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	38.87 mL	194.33 mL	388.65 mL
0.5 mM	7.77 mL	38.87 mL	77.73 mL
1 mM	3.89 mL	19.43 mL	38.87 mL
5 mM	0.78 mL	3.89 mL	7.77 mL

*The above data is based on the productmolecular weight 257.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.