Asenapine maleate

Catalog No. A10091

Asenapine maleate平对多种受体具有高亲和力（pKi），包括5-羟色胺5-HT1A（8.6），5-HT1B（8.4），5-HT2A（10.2），5-HT2B（9.8），5-HT2C（10.5），5 -HT5A（8.8），5-HT6（9.5）和5-HT7（9.9）受体，肾上腺素α1（8.9），α2A（8.9），α2B（9.5）和α2C（8.9）受体，多巴胺D1（ 8.9），D2（8.9），D3（9.4）和D4（9.0）受体以及组胺H1（9.0）和H2（8.2）受体。

Product Citations

Keisuke Obara, .et al. Inhibitory Effects of Antipsychotics on the Contractile Response to Acetylcholine in Rat Urinary Bladder Smooth Muscles, Biol Pharm Bull, 2021, 44, 1140-1150

Technical details

Catalog Num	A10091
M. Wt	401.84
Formula	C17H16ClNO.C4H4O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	85650-56-2
Synonyms
SMILES	CN1C[C@H]2[C@H](C1)C3=C(C=CC(=C3)Cl)OC4=CC=CC=C24.C(=C\C(=O)O)\C(=O)O

Biological Activity

Targets

Target	Value
5-HT2C	pki: 10.46
5-HT2A	pki: 10.15
5-HT7	pki: 9.94
5-HT2B	pki: 9.75
5-HT6	pki: 9.6
α2B-adrenergicreceptor	pki: 9.49
D3receptor	pki: 9.38
H1receptor	pki: 9
D4receptor	pki: 8.95
α1A-adrenergicreceptor	pki: 8.93
α2C-adrenergicreceptor	pki: 8.91
D2LReceptor	pki: 8.9
α2A-adrenergicreceptor	pki: 8.9
D1receptor	pki: 8.85
5-HT5A	pki: 8.84
D2SReceptor	pki: 8.84
5-HT1A	pki: 8.6
5-HT1B	pki: 8.4
H2receptor	pki: 8.21

Solubility *

In vitro	DMSO	78 mg/mL (194.1 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.89 mL	124.43 mL	248.86 mL
0.5 mM	4.98 mL	24.89 mL	49.77 mL
1 mM	2.49 mL	12.44 mL	24.89 mL
5 mM	0.5 mL	2.49 mL	4.98 mL

*The above data is based on the productmolecular weight 401.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.