AT7867

Catalog No. A10094

AT7867是AKT和下游激酶p70 S6激酶（p70S6K）以及蛋白激酶A的新型有效抑制剂。

Technical details

Catalog Num	A10094
M. Wt	337.9
Formula	C20H20ClN3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	857531-00-1
Synonyms	AT-7867
SMILES	C1CNCCC1(C2=CC=C(C=C2)C3=CNN=C3)C4=CC=C(C=C4)Cl

Biological Activity

AT7867是AKT和下游激酶p70 S6激酶（p70S6K）以及蛋白激酶A的新型有效抑制剂。

Targets

Target	Value
Akt2	IC50: 17nM
PKA	IC50: 20nM
Akt1	IC50: 32nM
Akt3	IC50: 47nM
p70S6K	IC50: 85nM
RSK1	IC50: >100nM
CDK2	IC50: >1μM
GSK-3β	IC50: >1μM
c-Src	IC50: >1μM
Chk1	IC50: >1μM
EGFR	IC50: >1μM
FGFR3	IC50: >1μM
MEK1	IC50: >1μM
PDK-1	IC50: >1μM
PI3Kβ	IC50: >1μM
PLK3	IC50: >1μM
RET	IC50: >1μM
SGK	IC50: >1μM
Tie-2	IC50: >1μM

Solubility *

In vitro (25°C)	DMSO	63 mg/mL (186.47 mM)
	Water	Insoluble
	Ethanol	5 mg/mL (14.79 mM)
In vivo	15% Captisol, pH 9	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	29.59 mL	147.97 mL	295.95 mL
0.5 mM	5.92 mL	29.59 mL	59.19 mL
1 mM	2.96 mL	14.8 mL	29.59 mL
5 mM	0.59 mL	2.96 mL	5.92 mL

*The above data is based on the productmolecular weight 337.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.