TC-S 7010 (Aurora A Inhibitor I)

Catalog No. A10100

TC-S 7010 (Aurora A Inhibitor I)是Aurora A激酶（AurA）的有效和选择性抑制剂，IC50值为3.4 nM（Aurora A），对Aurora B具有极高的选择性1000倍；用于研究Aurora A激酶的细胞作用的有用工具化合物。

Technical details

Catalog Num	A10100
M. Wt	588.1
Formula	C31H31ClFN7O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1158838-45-9
Synonyms	TC-S7010, TC-S-7010, TCS7010, TCS-7010
SMILES	CCN1CCN(CC1)C(=O)CC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=C(C=C4)C(=O)NC5=CC=CC=C5Cl)F

Biological Activity

Targets

Aurora A (Cell-free assay)	Aurora C (Cell-free assay)	Aurora B (Cell-free assay)
3.4 nM	432 nM	3.4 μM

Solubility *

In vitro (25°C)	DMSO	105 mg/mL (178.54 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5%DMSO+40%PEG300+5%Tween80+50%ddH2O	1.18 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17 mL	85.02 mL	170.04 mL
0.5 mM	3.4 mL	17 mL	34.01 mL
1 mM	1.7 mL	8.5 mL	17 mL
5 mM	0.34 mL	1.7 mL	3.4 mL

*The above data is based on the productmolecular weight 588.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.