AZD1480
Catalog No. A10110
AZD1480是一种新型有效的小型JAK2抑制剂,IC50为0.26 nM。
- Simona Moravcova, .et al. The Circadian Rhythms of STAT3 in the Rat Pineal Gland and Its Involvement in Arylalkylamine-N-Acetyltransferase Regulation, Life (Basel), 2021, Oct 18;11(10):1105 PMID: 34685476
Catalog Num | A10110 |
---|---|
M. Wt | 348.8 |
Formula | C14H14ClFN8 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 935666-88-9 |
Synonyms | |
SMILES | CC1=CC(=NN1)NC2=NC(=NC=C2Cl)N[C@@H](C)C3=NC=C(C=N3)F |
AZD1480是一种新型有效的小型JAK2抑制剂,IC50为0.26 nM。
Targets
JAK2 (Cell-free assay) | ||||
0.26 nM |
In vitro (25°C) | DMSO | Warmed: 68 mg/mL (194.96 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 4 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 28.67 mL | 143.35 mL | 286.7 mL |
0.5 mM | 5.73 mL | 28.67 mL | 57.34 mL |
1 mM | 2.87 mL | 14.33 mL | 28.67 mL |
5 mM | 0.57 mL | 2.87 mL | 5.73 mL |
*The above data is based on the productmolecular weight 348.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.