AZD6482

Catalog No. A10112

AZD6482是一种PI3Kβ抑制剂，(IC50 = 0.021M)。

Technical details

Catalog Num	A10112
M. Wt	408.5
Formula	C22H24N4O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1173900-33-8
Synonyms	AZD-6482
SMILES	CC1=CN2C(=O)C=C(N=C2C(=C1)[C@@H](C)NC3=CC=CC=C3C(=O)O)N4CCOCC4

Biological Activity

AZD6482是一种PI3Kβ抑制剂，(IC50 = 0.021M)。

Targets

PI3Kβ (Cell-free assay)	PI3Kδ (Cell-free assay)	DNA-PK (Cell-free assay)	PI3Kα (Cell-free assay)	PI3Kγ (Cell-free assay)
10 nM	80 nM	420 nM	870 nM	1090 nM

Solubility *

In vitro (25°C)	DMSO	74 mg/mL (181.16 mM)
	Water	Insoluble
	Ethanol	9 mg/mL (22.03 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.48 mL	122.4 mL	244.8 mL
0.5 mM	4.9 mL	24.48 mL	48.96 mL
1 mM	2.45 mL	12.24 mL	24.48 mL
5 mM	0.49 mL	2.45 mL	4.9 mL

*The above data is based on the productmolecular weight 408.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.