AZD8330

Catalog No. A10115

AZD8330是新型，选择性，非ATP竞争性MEK 1/2抑制剂，IC50为7 nM。阶段1。

Technical details

Catalog Num	A10115
M. Wt	461.2
Formula	C16H17FIN3O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	869357-68-6
Synonyms	AZD-8330
SMILES	CC1=CC(=C(N(C1=O)C)NC2=C(C=C(C=C2)I)F)C(=O)NOCCO

Biological Activity

AZD8330是新型，选择性，非ATP竞争性MEK 1/2抑制剂，IC50为7 nM。阶段1。

Targets

ERK phosphorylation	MEK1/2
0.4 nM	7 nM

Solubility *

In vitro (25°C)	DMSO	88 mg/mL (190.79 mM)
	Water	Insoluble
	Ethanol	88 mg/mL (190.79 mM)
In vivo	0.5% hydroxyethyl cellulose+0.1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.68 mL	108.41 mL	216.83 mL
0.5 mM	4.34 mL	21.68 mL	43.37 mL
1 mM	2.17 mL	10.84 mL	21.68 mL
5 mM	0.43 mL	2.17 mL	4.34 mL

*The above data is based on the productmolecular weight 461.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.