Bendamustine HCl (SDX-105)

Catalog No. A10124

Bendamustine Hydrochloride (SDX-105)是一种小分子双功能DNA烷基化剂,结合了氮芥菜碱功能和嘌呤类似物结构。苯达莫司汀具有致密的破坏DNA的功能,使其与用作抗增殖剂的其他化合物区分开来,这些功能被认为可通过多种不同途径(包括凋亡和有丝分裂灾难)促进细胞死亡。
Catalog Num A10124
M. Wt 394.7
Formula C16H21Cl2N3O2.HCl
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 3543-75-7
Synonyms Ribomustin, Treanda, SDX-105, Treakisym
SMILES CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCC(=O)O.Cl
Bendamustine Hydrochloride (SDX-105)是一种小分子双功能DNA烷基化剂,结合了氮芥菜碱功能和嘌呤类似物结构。苯达莫司汀具有致密的破坏DNA的功能,使其与用作抗增殖剂的其他化合物区分开来,这些功能被认为可通过多种不同途径(包括凋亡和有丝分裂灾难)促进细胞死亡。
Targets
DNA synthesis (Cell-free assay)
In vitro (25°C) DMSO 69 mg/mL (174.8 mM)
Water 2 mg/mL (5.06 mM)
Ethanol 15 mg/mL (37.99 mM)
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.34 mL 126.68 mL 253.36 mL
0.5 mM 5.07 mL 25.34 mL 50.67 mL
1 mM 2.53 mL 12.67 mL 25.34 mL
5 mM 0.51 mL 2.53 mL 5.07 mL

*The above data is based on the productmolecular weight 394.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.