BIBR 1532

Catalog No. A10140

BIBR 1532是一种选择性端粒酶抑制剂（人端粒酶，人RNA聚合酶I和人RNA聚合酶II + III的IC50值分别为93，> 100000和> 100000 nM）。

Product Citations

Hosoi T, .et al. Inhibition of telomerase causes vulnerability to endoplasmic reticulum stress-induced neuronal cell death, Neurosci Lett, 2016, Aug 26;629:241-244 PMID: 27443785

Technical details

Catalog Num	A10140
M. Wt	331.4
Formula	C21H17NO3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	321674-73-1
Synonyms	BIBR-1532, BIBR1532
SMILES	C/C(=C\C(=O)NC1=CC=CC=C1C(=O)O)/C2=CC3=CC=CC=C3C=C2

Biological Activity

BIBR 1532是一种选择性端粒酶抑制剂（人端粒酶，人RNA聚合酶I和人RNA聚合酶II + III的IC50值分别为93，> 100000和> 100000 nM）。

Targets

Telomerase (Cell-free assay)
100 nM

Solubility *

In vitro (25°C)	DMSO	58 mg/mL (175.03 mM)
	Water	Insoluble
	Ethanol	3 mg/mL (9.05 mM)
In vivo	5% DMSO+corn oil	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.18 mL	150.88 mL	301.75 mL
0.5 mM	6.04 mL	30.18 mL	60.35 mL
1 mM	3.02 mL	15.09 mL	30.18 mL
5 mM	0.6 mL	3.02 mL	6.04 mL

*The above data is based on the productmolecular weight 331.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.