BIIB021
Catalog No. A10143
BIIB021是一种口服全合成Hsp90抑制剂,可选择性和有效地抑制分子伴侣Hsp90。
- Ting-Yu Chang, .et al. A novel histone deacetylase inhibitor MPT0L184 dysregulates cell-cycle checkpoints and initiates unscheduled mitotic signaling, Biomed Pharmacother, 2021, Jun;138:111485 PMID: 33740521
- Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113
Catalog Num | A10143 |
---|---|
M. Wt | 318.8 |
Formula | C14H15ClN6O |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 848695-25-0 |
Synonyms | CNF2024 |
SMILES | CC1=CN=C(C(=C1OC)C)CN2C=NC3=C2N=C(N=C3Cl)N |
BIIB021是一种口服全合成Hsp90抑制剂,可选择性和有效地抑制分子伴侣Hsp90。
Targets
HSP90 | HSP90 | |||
1.7 nM(Ki) | 38 nM(EC50) |
In vitro (25°C) | DMSO | 60 mg/mL (188.22 mM) | |
Water | Insoluble | ||
Ethanol | 2 mg/mL (6.27 mM) | ||
In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 31.37 mL | 156.84 mL | 313.68 mL |
0.5 mM | 6.27 mL | 31.37 mL | 62.74 mL |
1 mM | 3.14 mL | 15.68 mL | 31.37 mL |
5 mM | 0.63 mL | 3.14 mL | 6.27 mL |
*The above data is based on the productmolecular weight 318.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.