BIX 02189

Catalog No. A10151

BIX 02189是选择性双重MEK5和ERK5（或BMK1）激酶抑制剂，对于MEK5，ERK5，TGFbR1和其他紧密相关的激酶，IC50值分别为1.5、59、580和> 6200 nM。

Product Citations

Mitsunori Miyazaki, .et al. TSC2/Rheb signaling mediates ERK-dependent regulation of mTORC1 activity in C2C12 myoblasts, FEBS Open Bio, 2017, Mar; 7(3): 424-433 PMID: 28286738

Technical details

Catalog Num	A10151
M. Wt	440.5
Formula	C27H28N4O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1094614-85-3
Synonyms	BIX02189, BIX-02189
SMILES	CN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N(C)C)NC2=O)/C4=CC=CC=C4

Biological Activity

BIX 02189是选择性双重MEK5和ERK5（或BMK1）激酶抑制剂，对于MEK5，ERK5，TGFbR1和其他紧密相关的激酶，IC50值分别为1.5、59、580和> 6200 nM。

Targets

Target	Value
MEK5	IC50: 1.5nM
ERK5	IC50: 59nM
TGFβR1	IC50: 580nM
MEK1	IC50: >6.2μM
MEK2	IC50: >6.2μM
ERK1	IC50: >6.2μM
JNK2	IC50: >6.2μM
EGFR	IC50: >6.3μM
STK16	IC50: >6.3μM

Solubility *

In vitro (25°C)	DMSO	Warmed: 56 mg/mL (127.11 mM)
	Water	Insoluble
	Ethanol	75 mg/mL (170.24 mM)
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.7 mL	113.51 mL	227.01 mL
0.5 mM	4.54 mL	22.7 mL	45.4 mL
1 mM	2.27 mL	11.35 mL	22.7 mL
5 mM	0.45 mL	2.27 mL	4.54 mL

*The above data is based on the productmolecular weight 440.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.