BMS-708163 (Avagacestat)

Catalog No. A10157

BMS-708163 (Avagacestat)是口服生物有效的，选择性的γ-分泌酶抑制剂，作用于Aβ40和Aβ42时，IC50分别为0.3 nM和0.27 nM。

Technical details

Catalog Num	A10157
M. Wt	520.8
Formula	C20H17ClF4N4O4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1146699-66-2
Synonyms	BMS708163
SMILES	C1=CC(=CC=C1S(=O)(=O)N(CC2=C(C=C(C=C2)C3=NOC=N3)F)[C@H](CCC(F)(F)F)C(=O)N)Cl

Biological Activity

BMS-708163 (Avagacestat)是口服生物有效的，选择性的γ-分泌酶抑制剂，作用于Aβ40和Aβ42时，IC50分别为0.3 nM和0.27 nM。

Targets

γ secretase(Aβ42)	γ secretase(Aβ40)
0.27 nM	0.3 nM

Solubility *

In vitro	DMSO	90 mg/mL (172.78 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.2 mL	96.01 mL	192.01 mL
0.5 mM	3.84 mL	19.2 mL	38.4 mL
1 mM	1.92 mL	9.6 mL	19.2 mL
5 mM	0.38 mL	1.92 mL	3.84 mL

*The above data is based on the productmolecular weight 520.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.