Bosutinib (SKI-606)

Catalog No. A10161

Bosutinib (SKI-606)是一种酪氨酸激酶抑制剂。

Product Citations

Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961

Technical details

Catalog Num	A10161
M. Wt	530.4
Formula	C26H29Cl2N5O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	380843-75-4
Synonyms	SKI-606, SKI606
SMILES	CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC

Biological Activity

Bosutinib (SKI-606)是一种酪氨酸激酶抑制剂。

Targets

Abl (Cell-free assay)	Src (Cell-free assay)
1 nM	1.2 nM

Solubility *

In vitro (25°C)	DMSO	93 mg/mL (175.31 mM)
	Water	Insoluble
	Ethanol	2 mg/mL (3.77 mM)
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.85 mL	94.27 mL	188.54 mL
0.5 mM	3.77 mL	18.85 mL	37.71 mL
1 mM	1.89 mL	9.43 mL	18.85 mL
5 mM	0.38 mL	1.89 mL	3.77 mL

*The above data is based on the productmolecular weight 530.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.