Brivanib alaninate (BMS-582664)

Catalog No. A10162

Brivanib alaninate (BMS-582664)是VEGFR和FGFR信号转导的双重酪氨酸激酶抑制剂。
Catalog Num A10162
M. Wt 441.5
Formula C22H24FN5O4
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 649735-63-7
Synonyms BMS582664
SMILES CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NN4C3=C(C(=C4)OC[C@@H](C)OC(=O)[C@H](C)N)C
Brivanib alaninate (BMS-582664)是VEGFR和FGFR信号转导的双重酪氨酸激酶抑制剂。
Targets
VEGFR2 Flk1 FGFR1 VEGFR1
25 nM89 nM148 nM380 nM
In vitro (25°C) DMSO 83 mg/mL (188 mM)
Water Insoluble
Ethanol 83 mg/mL (188 mM)
In vivo 0.5% methylcellulose+0.2% Tween 80 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.65 mL 113.25 mL 226.5 mL
0.5 mM 4.53 mL 22.65 mL 45.3 mL
1 mM 2.27 mL 11.33 mL 22.65 mL
5 mM 0.45 mL 2.27 mL 4.53 mL

*The above data is based on the productmolecular weight 441.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.