Cediranib (AZD2171)

Catalog No. A10185

Cediranib (AZD2171)是一种高效的VEGFR(KDR)抑制剂，此外对c-Kit和PDGFRβ也具有相似的抑制活性，对VEGFR的选择性比PDGFR-α，CSF-1R和Flt3分别高36倍，110倍和1000倍以上。

Product Citations

Majid Momeny, .et al. Cediranib, a pan-inhibitor of vascular endothelial growth factor receptors, inhibits proliferation and enhances therapeutic sensitivity in glioblastoma cells, Life Sci, 2021, Dec 15;287:120100 PMID: 34715143
Majid Momeny, .et al. Cediranib, an inhibitor of vascular endothelial growth factor receptor kinases, inhibits proliferation and invasion of prostate adenocarcinoma cells, Eur J Pharmacol, 2020, 882:173298

Technical details

Catalog Num	A10185
M. Wt	450.5
Formula	C25H27FN4O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	288383-20-0
Synonyms	Recentin
SMILES	CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCC5

Biological Activity

Targets

Target	Value
VEGFR2/KDR	IC50: 0.5nM
c-Kit	IC50: 2nM
VEGFR3/FLT4	IC50: <=3nM
VEGFR1/FLT1	IC50: 5nM
PDGFRβ	IC50: 5nM
FGFR1	IC50: 26nM
PDGFRα	IC50: 36nM
CSF-1R	IC50: 110nM
Src	IC50: 130nM
Abl	IC50: 260nM
FLT3	IC50: >1μM
HER2/ErbB2	IC50: >1μM
CDK2	IC50: >1μM
CDK4	IC50: >1μM
EGFR	IC50: 1.6μM
AuroraA	IC50: >10μM
AuroraB	IC50: >10μM
MEK	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	80 mg/mL (177.57 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+50% PEG 300+5% Tween+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.2 mL	110.99 mL	221.98 mL
0.5 mM	4.44 mL	22.2 mL	44.4 mL
1 mM	2.22 mL	11.1 mL	22.2 mL
5 mM	0.44 mL	2.22 mL	4.44 mL

*The above data is based on the productmolecular weight 450.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.