Cerubidine (Daunorubicin HCl, Rubidomycin HCl)

Catalog No. A10194

Cerubidine (Daunorubicin HCl,Rubidomycin HCl)通过插入和抑制大分子生物合成与DNA相互作用。这抑制了拓扑异构酶II的进程，该酶使DNA中的超螺旋松弛以进行转录。

Technical details

Catalog Num	A10194
M. Wt	564.0
Formula	C27H29NO10.HCl
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	23541-50-6
Synonyms	Daunorubicin HCl, Rubidomycin HCl
SMILES	C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)C)O)N)O.Cl

Biological Activity

Cerubidine (Daunorubicin HCl,Rubidomycin HCl)通过插入和抑制大分子生物合成与DNA相互作用。这抑制了拓扑异构酶II的进程，该酶使DNA中的超螺旋松弛以进行转录。

Targets

DNA synthesis (Cell-free assay)
20 nM(Ki)

Solubility *

In vitro (25°C)	DMSO	93 mg/mL (164.9 mM)
	Water	93 mg/mL (164.9 mM)
	Ethanol	Insoluble
In vivo	Saline	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.73 mL	88.65 mL	177.3 mL
0.5 mM	3.55 mL	17.73 mL	35.46 mL
1 mM	1.77 mL	8.87 mL	17.73 mL
5 mM	0.35 mL	1.77 mL	3.55 mL

*The above data is based on the productmolecular weight 564.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.