Dovitinib Dilactic acid (TKI258 Dilactic acid)

Catalog No. A10198

Dovitinib是一种小分子多靶点酪氨酸激酶抑制剂，可抑制通过ZNF198-FGFR1或BCR-FGFR1转化为IL3独立性的Ba / F3细胞，IC50值分别为150 nM和90 nM。

Technical details

Catalog Num	A10198
M. Wt	572.6
Formula	C21H21FN6O.2C3H6O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	852433-84-2
Synonyms	CHIR-258, TKI258
SMILES	CC(C(=O)O)O.CC(C(=O)O)O.CN1CCN(CC1)C2=CC3=C(C=C2)N/C(=C/4\C(=C5C(=NC4=O)C=CC=C5F)N)/N3

Biological Activity

Dovitinib是一种小分子多靶点酪氨酸激酶抑制剂，可抑制通过ZNF198-FGFR1或BCR-FGFR1转化为IL3独立性的Ba / F3细胞，IC50值分别为150 nM和90 nM。

Targets

Target	Value
FLT3	IC50: 1nM
c-Kit	IC50: 2nM
FGFR1	IC50: 8nM
VEGFR3/FLT4	IC50: 8nM
FGFR3	IC50: 9nM
VEGFR1/FLT1	IC50: 10nM
VEGFR2/Flk1	IC50: 13nM
PDGFRβ	IC50: 27nM
CSF-1R/c-Fms	IC50: 36nM
PDGFRα	IC50: 210nM
Insulin Receptor	IC50: 2μM
EGFR	IC50: 2μM
c-Met	IC50: >3μM
EphA2	IC50: 4μM
Tie-2	IC50: 4μM
IGF-1R	IC50: >10μM
HER2	IC50: >10μM

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.46 mL	87.32 mL	174.64 mL
0.5 mM	3.49 mL	17.46 mL	34.93 mL
1 mM	1.75 mL	8.73 mL	17.46 mL
5 mM	0.35 mL	1.75 mL	3.49 mL

*The above data is based on the productmolecular weight 572.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

Dovitinib Dilactic acid (TKI258 Dilactic acid)

Technical details

Biological Activity

Targets

Preparing Stock Solutions