CHIR-99021
Catalog No. A10199
CHIR99021是一种GSK-3α和GSK-3β抑制剂,IC50值分别为10和6.7 nM。
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Catalog Num | A10199 |
---|---|
M. Wt | 465.3 |
Formula | C22H18Cl2N8 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 252917-06-9 |
Synonyms | GSK-3 Inhibitor XVI, CT 99021, CHIR99021 |
SMILES | CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N |
CHIR99021是一种GSK-3α和GSK-3β抑制剂,IC50值分别为10和6.7 nM。
Targets
GSK-3β | GSK-3α | |||
6.7 nM | 10 nM |
In vitro (25°C) | DMSO | Warmed: 9 mg/mL (19.33 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 4% DMSO+30% PEG 300+ddH2O | 3.3 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 21.49 mL | 107.46 mL | 214.92 mL |
0.5 mM | 4.3 mL | 21.49 mL | 42.98 mL |
1 mM | 2.15 mL | 10.75 mL | 21.49 mL |
5 mM | 0.43 mL | 2.15 mL | 4.3 mL |
*The above data is based on the productmolecular weight 465.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.