CHIR-99021

Catalog No. A10199

CHIR99021是一种GSK-3α和GSK-3β抑制剂,IC50值分别为10和6.7 nM。
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Catalog Num A10199
M. Wt 465.3
Formula C22H18Cl2N8
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 252917-06-9
Synonyms GSK-3 Inhibitor XVI, CT 99021, CHIR99021
SMILES CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N
CHIR99021是一种GSK-3α和GSK-3β抑制剂,IC50值分别为10和6.7 nM。
Targets
GSK-3β GSK-3α
6.7 nM10 nM
In vitro (25°C) DMSO Warmed: 9 mg/mL (19.33 mM)
Water Insoluble
Ethanol Insoluble
In vivo 4% DMSO+30% PEG 300+ddH2O 3.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.49 mL 107.46 mL 214.92 mL
0.5 mM 4.3 mL 21.49 mL 42.98 mL
1 mM 2.15 mL 10.75 mL 21.49 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

*The above data is based on the productmolecular weight 465.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.