Cilomilast (SB-207499)

Catalog No. A10216

Cilomilast (SB-207499)可作为选择性磷酸二酯酶4抑制剂，具有抗炎作用。可针对与COPD相关的支气管收缩，粘液分泌过多和气道重塑。

Technical details

Catalog Num	A10216
M. Wt	343.4
Formula	C20H25NO4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	153259-65-5
Synonyms	SB207499, Ariflo, SB-207,499
SMILES	COC1=C(C=C(C=C1)C2(CCC(CC2)C(=O)O)C#N)OC3CCCC3

Biological Activity

Cilomilast (SB-207499)可作为选择性磷酸二酯酶4抑制剂，具有抗炎作用。可针对与COPD相关的支气管收缩，粘液分泌过多和气道重塑。

Targets

Solubility *

In vitro (25°C)	DMSO	64 mg/mL (186.36 mM)
	Water	Insoluble
	Ethanol	47 mg/mL (136.85 mM)
In vivo	5% DMSO+95% Corn oil	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	29.12 mL	145.6 mL	291.21 mL
0.5 mM	5.82 mL	29.12 mL	58.24 mL
1 mM	2.91 mL	14.56 mL	29.12 mL
5 mM	0.58 mL	2.91 mL	5.82 mL

*The above data is based on the productmolecular weight 343.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.