Cisplatin

Catalog No. A10221

Cisplatin是一种无机铂络合物，在肿瘤细胞中能够通过形成DNA加合物抑制 DNA synthesis。建议使用DMF溶解，而不是DMSO。

Product Citations

RUI-NING LIANG, .et al. Kidney mesenchymal stem cells alleviate cisplatin-induced kidney injury and apoptosis in rats, Research Square, 2022, July 6th
Wei Zeng, .et al. Lidocaine suppresses the malignant behavior of gastric cancer cells via the c-Met/c-Src pathway, Exp Ther Med, 2021, May; 21(5): 424 PMID: 33747163
Yi-Ru Pan, .et al. ATM Inhibitor Suppresses Gemcitabine-Resistant BTC Growth in a Polymerase θ Deficiency-Dependent Manner, Biomolecules, 2020, Nov 9;10(11):1529 PMID: 33182492
Amnah Alshangiti, .et al. The dietary flavonoid isoliquiritigenin is a potent cytotoxin for human neuroblastoma cells, Neuronal Signal, 2019, 2019
Calhelha RC, .et al. Mathematical models of cytotoxic effects in endpoint tumor cell line assays: critical assessment of the application of a single parametric value as a standard criterion to quantify the dose-response effects and new unexplored proposal formats, Analyst, 2017, Oct 23;142(21):4124-4141 PMID: 28991301
Pi-Lin Sung, .et al. Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma, Oncotarget, 2016, Jan 26; 7(4): 4036-4047 PMID: 26716408

Technical details

Catalog Num	A10221
M. Wt	300.1
Formula	Cl2H4N2Pt
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	15663-27-1
Synonyms	cisplatinum, CDDP, cis-diamminedichloroplatinum(II)
SMILES	N.N.Cl[Pt+2]Cl

Biological Activity

Cisplatin是一种无机铂络合物，在肿瘤细胞中能够通过形成DNA加合物抑制 DNA synthesis。建议使用DMF溶解，而不是DMSO。

Targets

DNA synthesis (Tumor cells)

Solubility *

In vitro	DMSO	56 mg/mL (186.63 mM)
	Water	DMF: 11 mg/mL (36.66 mM)
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	33.32 mL	166.61 mL	333.22 mL
0.5 mM	6.66 mL	33.32 mL	66.64 mL
1 mM	3.33 mL	16.66 mL	33.32 mL
5 mM	0.67 mL	3.33 mL	6.66 mL

*The above data is based on the productmolecular weight 300.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.