Cladribine

Catalog No. A10223

Cladribine是一种腺苷脱氨酶抑制剂，从而干扰细胞处理DNA的能力。

Technical details

Catalog Num	A10223
M. Wt	285.7
Formula	C10H12ClN5O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	4291-63-8
Synonyms	2-chlorodeoxyadenosine, Leustatin
SMILES	C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2N=C(N=C3N)Cl)CO)O

Biological Activity

Cladribine是一种腺苷脱氨酶抑制剂，从而干扰细胞处理DNA的能力。

Targets

Adenosine deaminase (MM1.S cells)	Adenosine deaminase (RPMI8226 cells)	Adenosine deaminase (U266 cells)
0.18 μM	0.75 μM	2.43 μM

Solubility *

In vitro (25°C)	DMSO	52 mg/mL (182.01 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+30% PEG 300+1% Tween 80+H2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	35 mL	175.01 mL	350.02 mL
0.5 mM	7 mL	35 mL	70 mL
1 mM	3.5 mL	17.5 mL	35 mL
5 mM	0.7 mL	3.5 mL	7 mL

*The above data is based on the productmolecular weight 285.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.