Clofarabine

Catalog No. A10228

Clofarabine具有抗肿瘤活性的第二代嘌呤核苷类似物。

Product Citations

Xie J, .et al. Optimization of a clofarabine-based drug combination regimen for the preclinical evaluation of pediatric acute lymphoblastic leukemia, Pediatr Blood Cancer, 2019, Dec 25:e28133 PMID: 31876116

Technical details

Catalog Num	A10228
M. Wt	303.7
Formula	C10H11ClFN5O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	123318-82-1
Synonyms	Clolar, Evoltra
SMILES	C1=NC2=C(N1[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)F)N=C(N=C2N)Cl

Biological Activity

Clofarabine具有抗肿瘤活性的第二代嘌呤核苷类似物。

Targets

Ribonucleotide reductase
65 nM

Solubility *

In vitro (25°C)	DMSO	55 mg/mL (181.11 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300 +1% Tween 80+ddH2O	7 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.93 mL	164.64 mL	329.27 mL
0.5 mM	6.59 mL	32.93 mL	65.85 mL
1 mM	3.29 mL	16.46 mL	32.93 mL
5 mM	0.66 mL	3.29 mL	6.59 mL

*The above data is based on the productmolecular weight 303.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.