CYC116 (CYC-116)

Catalog No. A10248

CYC116 (CYC-116)是一种有效的Aurora A/B抑制剂，Ki为8.0 nM/9.2 nM，对VEGFR2(Ki为44 nM)作用稍弱。

Technical details

Catalog Num	A10248
M. Wt	368.5
Formula	C18H20N6OS
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	693228-63-6
Synonyms	CYC-116
SMILES	CC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4

Biological Activity

CYC116 (CYC-116)是一种有效的Aurora A/B抑制剂，Ki为8.0 nM/9.2 nM，对VEGFR2(Ki为44 nM)作用稍弱。

Targets

Target	Value
AuroraA	ki: 8nM
AuroraB	ki: 9nM
VEGFR2	ki: 44nM
FLT3	ki: 44nM
CDK2/CyclinE	ki: 0.39μM
CDK9/CyclinT	ki: 0.48μM
p70S6K	ki: 0.54μM
Src	ki: 0.82μM
CDK4/CyclinD	ki: 1.09μM
LCK	ki: 2.8μM
CDK1/CyclinB	ki: >10μM
CDK7/CyclinH	ki: >10μM
Abl	ki: >10μM
Akt	ki: >10μM
CaMKII	ki: >10μM
CK2	ki: >10μM
ERK2	ki: >10μM
GSK-3α	ki: >10μM
GSK-3β	ki: >10μM
PKA	ki: >10μM
PKC	ki: >10μM
SAPK2A(p38α)	ki: >10μM
PLK1	ki: >10μM

Solubility *

In vitro (25°C)	DMSO	Warmed: 24 mg/mL (65.13 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.14 mL	135.69 mL	271.37 mL
0.5 mM	5.43 mL	27.14 mL	54.27 mL
1 mM	2.71 mL	13.57 mL	27.14 mL
5 mM	0.54 mL	2.71 mL	5.43 mL

*The above data is based on the productmolecular weight 368.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.