Cyclopamine

Catalog No. A10249

Cyclopamine是一种特异性的Hedgehog (Hh)信号通路拮抗剂，作用于Smoothened (Smo)，IC50为46 nM。Cyclopamine 抑制Hedgehog信号通路， IC50 为46 nM。

Technical details

Catalog Num	A10249
M. Wt	411.6
Formula	C27H41NO2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	4449-51-8
Synonyms	11-deoxojervine
SMILES	C[C@H]1C[C@@H]2[C@H]([C@H]([C@]3(O2)CC[C@H]4[C@@H]5CC=C6C[C@H](CC[C@@]6([C@H]5CC4=C3C)C)O)C)NC1

Biological Activity

Cyclopamine是一种特异性的Hedgehog (Hh)信号通路拮抗剂，作用于Smoothened (Smo)，IC50为46 nM。Cyclopamine 抑制Hedgehog信号通路， IC50 为46 nM。

Targets

Smoothened (TM3Hh12 cells)
46 nM

Solubility *

In vitro	DMSO	Insoluble
	Water	DMF Warmed: 9 mg/mL (21.86 mM)
	Ethanol	Warmed: 2 mg/mL (4.85 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.3 mL	121.48 mL	242.95 mL
0.5 mM	4.86 mL	24.3 mL	48.59 mL
1 mM	2.43 mL	12.15 mL	24.3 mL
5 mM	0.49 mL	2.43 mL	4.86 mL

*The above data is based on the productmolecular weight 411.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.