Danoprevir (RG7227)

Catalog No. A10284

Danoprevir (RG7227)是HCV NS3/4A丝氨酸蛋白酶的有效抑制剂。

Product Citations

Mahim Khan, .et al. Hesperidin identified from Citrus extracts potently inhibits HCV genotype 3a NS3 protease, BMC Complement Med Ther, 2022, Apr 2;22(1):98 PMID: 35366855
Inês GARCEZ PALHA, .et al. An in vivo translation-reporter system for the study of protein synthesis in zebrafish embryos, Biol Open, 2018, Nov 7 PMID: 30404898
Hui Shen, .et al. Inhibitory Effects of Caffeic Acid Phenethyl Ester Derivatives on Replication of Hepatitis C Virus, PLoS One., 2013, 8(12): e82299 PMID: 24358168

Technical details

Catalog Num	A10284
M. Wt	717.9
Formula	C35H48FN5O8S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	850876-88-9
Synonyms	RG7227, ITMN-191, RO5190591
SMILES	CC(C)(C)OC(=O)N[C@H]1CCCCC/C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]3C[C@H](CN3C1=O)OC(=O)N4CC5=C(C4)C(=CC=C5)F)C(=O)NS(=O)(=O)C6CC6

Biological Activity

Danoprevir (RG7227)是HCV NS3/4A丝氨酸蛋白酶的有效抑制剂。

Targets

HCV NS3/4A protease
0.2 nM-3.5 nM

Solubility *

In vitro	DMSO	124 mg/mL (169.43 mM)
	Water	Insoluble
	Ethanol	124 mg/mL (169.43 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.93 mL	69.65 mL	139.3 mL
0.5 mM	2.79 mL	13.93 mL	27.86 mL
1 mM	1.39 mL	6.96 mL	13.93 mL
5 mM	0.28 mL	1.39 mL	2.79 mL

*The above data is based on the productmolecular weight 717.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.