Daphnetin

Catalog No. A10286

Daphnetin是一种香豆素类似物，可作为几种蛋白激酶的抑制剂。它在体外抑制EGFR激酶（IC50 = 7.67 ?M），PKA（IC50 = 9.33 ?M）和PKC（IC50 = 25 ?M）。蜂胶对EGFR激酶的抑制作用与ATP竞争，对肽底物没有竞争性。还可以用作有效的抗氧化剂和抗疟疾剂。

Technical details

Catalog Num	A10286
M. Wt	178.1
Formula	C9H6O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	486-35-1
Synonyms	7,8-dihydroxycoumarin
SMILES	C1=CC(=C(C2=C1C=CC(=O)O2)O)O

Biological Activity

Targets

EGFR	PKA	PKC
7.67 μM	9.33 μM	25.01 μM

Solubility *

In vitro	DMSO	33 mg/mL (185.24 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	56.15 mL	280.74 mL	561.48 mL
0.5 mM	11.23 mL	56.15 mL	112.3 mL
1 mM	5.61 mL	28.07 mL	56.15 mL
5 mM	1.12 mL	5.61 mL	11.23 mL

*The above data is based on the productmolecular weight 178.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.