Deforolimus (Ridaforolimus)

Catalog No. A10295

Deforolimus (Ridaforolimus)是mTOR蛋白的研究目标靶向小分子抑制剂。阻断mTOR通过干扰细胞生长，分裂，代谢和血管生成，在癌细胞中产生饥饿样的效应。

Technical details

Catalog Num	A10295
M. Wt	990.2
Formula	C53H84NO14P
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	572924-54-0
Synonyms	AP23573, MK-8669, MK8669
SMILES	C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OP(=O)(C)C)C)/C)O)OC)C)C)/C)OC

Biological Activity

Deforolimus (Ridaforolimus)是mTOR蛋白的研究目标靶向小分子抑制剂。阻断mTOR通过干扰细胞生长，分裂，代谢和血管生成，在癌细胞中产生饥饿样的效应。

Targets

mTOR (HT-1080 cells)
0.2 nM

Solubility *

In vitro (25°C)	DMSO	196 mg/mL (197.93 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+40% PEG 300+5% Tween 80+50% H2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	10.1 mL	50.49 mL	100.99 mL
0.5 mM	2.02 mL	10.1 mL	20.2 mL
1 mM	1.01 mL	5.05 mL	10.1 mL
5 mM	0.2 mL	1.01 mL	2.02 mL

*The above data is based on the productmolecular weight 990.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.