Diclofenac sodium

Catalog No. A10304

Diclofenac Sodium是一种非选择性的COX抑制剂，完整细胞中的COX-1和-2的IC50分别为0.5μg/ml和0.5μg/ml，作用于绵羊COX-1和COX-2， IC50分别为60和220 nM，用作非甾体类抗炎药（NSAID）来减轻疼痛和减轻疼痛肿胀发炎。

Technical details

Catalog Num	A10304
M. Wt	318.13
Formula	C14H10Cl2NNaO2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	15307-79-6
Synonyms
SMILES	C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]

Biological Activity

Targets

COX-1	COX-2
60 nM	200 nM

Solubility *

In vitro	DMSO	54 mg/mL (169.74 mM)
	Water	12 mg/mL (37.71 mM)
	Ethanol	54 mg/mL (169.74 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.43 mL	157.17 mL	314.34 mL
0.5 mM	6.29 mL	31.43 mL	62.87 mL
1 mM	3.14 mL	15.72 mL	31.43 mL
5 mM	0.63 mL	3.14 mL	6.29 mL

*The above data is based on the productmolecular weight 318.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.