Droxinostat

Catalog No. A10337

Droxinostat是HDAC3,HDAC6和HDAC8的选择性抑制剂,显示出可比较的HDAC6和HDAC8抑制作用,IC50分别为2.47和1.46μmol/ L。
Catalog Num A10337
M. Wt 243.7
Formula C11H14ClNO3
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 99873-43-5
Synonyms
SMILES CC1=C(C=CC(=C1)Cl)OCCCC(=O)NO
Droxinostat是HDAC3,HDAC6和HDAC8的选择性抑制剂,显示出可比较的HDAC6和HDAC8抑制作用,IC50分别为2.47和1.46μmol/ L。
Targets
Target Value
HDAC8IC50: 1.46μM
HDAC6IC50: 2.47μM
HDAC3IC50: 16.9μM
HDAC9IC50: >20μM
HDAC10IC50: >20μM
HDAC1IC50: >20μM
HDAC2IC50: >20μM
HDAC4IC50: >20μM
HDAC5IC50: >20μM
HDAC7IC50: >20μM
In vitro (25°C) DMSO 47 mg/mL (192.86 mM)
Water Insoluble
Ethanol 47 mg/mL (192.86 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 41.03 mL 205.17 mL 410.34 mL
0.5 mM 8.21 mL 41.03 mL 82.07 mL
1 mM 4.1 mL 20.52 mL 41.03 mL
5 mM 0.82 mL 4.1 mL 8.21 mL

*The above data is based on the productmolecular weight 243.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.