Oxaliplatin (Eloxatin)

Catalog No. A10346

Oxaliplatin (Eloxatin)是一种DNA/RNA Synthesis抑制剂，具有抗结肠癌的抗肿瘤活性。

Product Citations

Mohamed Elbadawy, .et al. Anti-cancer activity of amorphous curcumin preparation in patient-derived colorectal cancer organoids, Biomed Pharmacother, 2021, Oct;142:112043 PMID: 34411919
Tatsuya Usui, .et al. Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture, Int J Mol Sci, 2018, Apr; 19(4): 1098 PMID: 29642386
Shimokawa M, .et al. Visualization and targeting of LGR5+ human colon cancer stem cells, Nature, 2017, May 11;545(7653):187-192 PMID: 28355176
Eri Takiguchi, .et al. Growth inhibitory effect of the Src inhibitor dasatinib in combination with anticancer agents on uterine cervical adenocarcinoma cells, Exp Ther Med, 2017, Nov; 14(5): 4293-4299 PMID: 29067110

Technical details

Catalog Num	A10346
M. Wt	397.3
Formula	C8H14N2O4Pt
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	61825-94-3
Synonyms
SMILES	O=C3O[Pt]1(N[C@@H]2CCCC[C@H]2N1)OC3=O

Biological Activity

Oxaliplatin (Eloxatin)是一种DNA/RNA Synthesis抑制剂，具有抗结肠癌的抗肿瘤活性。

Targets

DNA synthesis (RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, HT-144 cells)

Solubility *

In vitro (25°C)	DMSO	Insoluble
	Water	Warmed: 3 mg/mL (7.55 mM)
	Ethanol	<1 mg/mL
In vivo	5% glucose (with warming)	2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.17 mL	125.85 mL	251.7 mL
0.5 mM	5.03 mL	25.17 mL	50.34 mL
1 mM	2.52 mL	12.58 mL	25.17 mL
5 mM	0.5 mL	2.52 mL	5.03 mL

*The above data is based on the productmolecular weight 397.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.