Elvitegravir (GS-9137)

Catalog No. A10347

Elvitegravir (GS-9137)是一种有效的抑制剂，可抑制人类1型免疫缺陷病毒（HIV-1）整合酶介导的整合链转移步骤。

Product Citations

Lea El Khoury, .et al. Spectrometric and computational studies of the binding of HIV-1 integrase inhibitors to viral DNA extremities, PeerJ Preprints, 2019, 7:e27833v1
El Khoury L, .et al. The inhibition process of HIV-1 integrase by diketoacids molecules: Understanding the factors governing the better efficiency of dolutegravir, Biochem Biophys Res Commun, 2017, Jul 1;488(3):433-438 PMID: 28478035

Technical details

Catalog Num	A10347
M. Wt	447.9
Formula	C23H23ClFNO5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	697761-98-1
Synonyms	GS9137
SMILES	CC(C)[C@@H](CO)N1C=C(C(=O)C2=CC(=C(C=C21)OC)CC3=C(C(=CC=C3)Cl)F)C(=O)O

Biological Activity

Elvitegravir (GS-9137)是一种有效的抑制剂，可抑制人类1型免疫缺陷病毒（HIV-1）整合酶介导的整合链转移步骤。

Targets

HIV-1 IIIB (Cell-free assay)	HIV-2 ROD (Cell-free assay)	HIV-2 EHO (Cell-free assay)
0.7 nM	1.4 nM	2.8 nM

Solubility *

In vitro	DMSO	85 mg/mL (189.78 mM)
	Water	Insoluble
	Ethanol	33 mg/mL (73.67 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.33 mL	111.63 mL	223.26 mL
0.5 mM	4.47 mL	22.33 mL	44.65 mL
1 mM	2.23 mL	11.16 mL	22.33 mL
5 mM	0.45 mL	2.23 mL	4.47 mL

*The above data is based on the productmolecular weight 447.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.