LY317615 (Enzastaurin)

Catalog No. A10356

LY317615（Enzastaurin）是一种有效的，选择性的PKCβ抑制剂，具有抗增殖活性（IC50 =?6 nM）。

Technical details

Catalog Num	A10356
M. Wt	515.6
Formula	C32H29N5O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	170364-57-5
Synonyms	LY-317615
SMILES	CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)C6CCN(CC6)CC7=CC=CC=N7

Biological Activity

LY317615（Enzastaurin）是一种有效的，选择性的PKCβ抑制剂，具有抗增殖活性（IC50 =?6 nM）。

Targets

PKCβ (Cell-free assay)	PKCα (Cell-free assay)	PKCγ (Cell-free assay)	PKCε (Cell-free assay)
6 nM	39 nM	83 nM	110 nM

Solubility *

In vitro (25°C)	DMSO	29 mg/mL (56.24 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	15% Captisol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.39 mL	96.97 mL	193.95 mL
0.5 mM	3.88 mL	19.39 mL	38.79 mL
1 mM	1.94 mL	9.7 mL	19.39 mL
5 mM	0.39 mL	1.94 mL	3.88 mL

*The above data is based on the productmolecular weight 515.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.